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Silicone Scar Clinical Information

Since the introduction of silicone in the early 1980s, its therapeutic effects on the treatment and prevention of abnormal scarring has been well documented.

Silicone gel is the main stay of treatment for Plastic Surgeons and Dermatologists and it is the unique properties of silicone that make it effective and safe for treating and preventing scars1,2.

The summaries below all show that ScarMD® Silicone Scar Gel can be used effectively to treat and prevent scars.

ScarMD® Scar Gel – Mode of Action:

Silicone in various formats has been used since the 1980′s to treat red and raised scars. The efficacy of silicone has been established in many peer reviewed studies. Recent work has focused on the mode of action of silicone on the treatment of scars. The most recent theory is that occlusion is the main factor that contributes to the effectiveness of silicone during the scar treatment. The occlusion of silicone has been proven to reduce the overproduction of collagen by regulating the transforming growth factor5.

Data has proven that although this is the main mode of action, other semi-occlusive dressings are not as effective as silicone at treating scars. This implies that there is something specific about silicone that above all else has an effect on flattening scars, reducing the redness and minimizing the pain and itchiness.


ScarMD® Silicone Scar Gel is a unique formulation of silicone that dries to form an ultra-thin layer on the skin. This provides a semi-occlusive layer, with similar breathability to the skin. This modifies the factors involved in healing to normalize the production of collagen. This in turn reduces the redness of abnormal scars, decreases their volume and reduces the pain and itchiness.

Clinical studies have proven the effectiveness of silicone at treating all types of scars, whether they are new scars, old scars, large scars or small scars.

The recommendations from the clinical reviews are clear – silicone should be used as the first line defense against all types of scars.3


  1. Sawada Y, Sone K. Hydration and occlusion treatment for hypertrophic scars and keloids. Br J Plast Surg. 1992;45:599–603.
  2. Fulton JE., Jr Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars. Dermatol Surg. 1995;21:947–51.
  3. Mustoe TA, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002;110:560–71.
  4. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61:4–17.
    Wound Repair Regen. 2010 Mar-Apr;18(2):235-44.Occlusion regulates epidermal cytokine production and inhibits scar formation.
  5. Dermatol Surg. 1996 Sep;22(9):775-8.A randomized controlled trial of hydrocolloid dressing in the treatment of hypertrophic scars and keloids
  6. Massimo Signorini, M.D., and Matteo Tretti Clementoni, M.D. Clinical Evaluation of a New Self-Drying Silicone Gel in the Treatment of Scars: A Preliminary Report. Aesth. Plast. Surg. 2007 (31):183-187

Associated Graphs (located in folder ”Scar Gel Clinical Evaluation Graphs”)

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